Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2027 | 2027-30722 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, L74I, M184V, T215F | K219Q | A98G | T39A, I94L, V118I, K122E, Q174N, I202V, R211RT, F214L, D218E, L228H, Q242H, V245M |
| >2027-30722| codons 38-247 CAELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKIVDFRELNKRTQDFWEVQLGLPHP GGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKNNPDIVIYQYVDDLYVGSDLEIGQHRTKVEELRQHLLTWGLFTP EQKHQKEPPFHWMGYELHPDKWTVHPIMLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I54V, V82A, L90M | V11I, K43T, F53L, L89V | L10V, I13V, K20V, M36I, Q61H, L63P, A71I, Q92K |
| >2027-30722| codons 4-99 TLWQRPVITVKIGGQLVEALLDTGADDTILEEINLPGRWTPKIIGGIGGLVKVRQYDHIP IEICGHKIIGTVLVGPTPANIIGRNVMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |