Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2281 | 2281-30822 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, I84V, L90M | L10F, V11I, G73S, L89V | I13V, I15V, K20V, E34Q, M36I, R57K, I62V, L63P, A71V, I72L, P79AD |
| >2281-30822| codons 4-99 TLWQRPFITVKVGGQLVEALLDTGADDTVLQEINLPGRWKPKIIGGIGGFVKVKQYDQVP IEICGHKVLSTVVVGDTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | K219N | Y181C | V108VI | T39K, K43E, V60I, K64KR, A98S, K101Q, V118I, K122E, D123S, I135T, T200A, H208Y, D218E, K223KQ, L228H, Q242H |
| >2281-30822| codons 38-247 CKELEEEGKISKIGPENPYNTPIFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP SGLQKKKSVTILDVGDAYFSIPLDESFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIGQHRAKIEELRQYLWRWGFYTP ENKHQQEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |