Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2279 | 2279-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V | L33F, L89V | L10I, G16A, K20R, E35D, M36I, K55KR, R57K, L63P, H69Q, A71V, T74S, Q92K, I93L | N88E |
| >2279-30819| codons 4-99 TLWQRPIVTIKIAGQLREALLDTGADDTVFEDINLPGRWKPKIIGGIGGFVRVKQYDQIP IEICGQKVIGSVLVGPTPVNVIGREVLTKLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K103N, Y181YC | K43E, K64KR, V118I, K122KE, D123E, I135T, V179I, H208Y, R211K, K223T, L228R |
| >2279-30819| codons 38-247 CTELEEEGKISKIGPENPYNTPVFAIRKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIIICQYVDDLYVGSDLEIGQHRTKIEELRQYLWKWGFYTP DKKHQTEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |