Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2280 | 2280-30819 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, V75T, M184V, T215F | K219E | Y181C | V108VI | K64R, D123E, D177E, I178L, K223Q, L228H | K166A |
| >2280-30819| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIRKKNSTRWRKITDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTILDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTAILEPFRKQNPELVICQYVDDLYVGSDLEIGQHRTKIEELRQHLLRWGFFTP DEKHQQEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48V, I54V, V82A | L24I | L10I, I15V, L63LP, I64IV, I72IV |
| >2280-30819| codons 4-99 TLWQRPIVTIKVGGQLKEALIDTGADDTVLEEMNLPGRWKPKLIVGIGGFVKVRQYDQIP VEICGHKAVGTVLVGPTPANIIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |