Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1329 | 1329-30715 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I84V, L90M | F53L | L10I, T12TP, K20R, E35D, M36I, N37ND, R41K, K43KI, K55KR, I62V, I64IV, K70KE, A71IV, P79PS, V82I, T91S, Q92QK, I93L, C95F |
| >1329-30715| codons 4-99 TLWQRPIVPIKIGGQLREALLDTGADDTVLEDIDLPGKWIPKIIGGIGGLIRVRQYDQVL VEICGHEVIGTVLVGSTPINVIGRNLMSKLGFTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, T215F | V75L, K219E | K103N, Y181C, G190A | V179F | K122KE, D192DY, T200A, H208Y, R211K, L228R, V245M |
| >1329-30715| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLLDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIFICQYMDDLYVASYLEIGQHRAKIEELRQYLLKWGFFTP DEKHQKEPPFRWMGYELHPDKWTVQPIMLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |