<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1327 1327-30708 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70KR, L74V, M184V, T215F K219Q K101DEHQ, Y181C, G190S   V106VI, V118I, K122E, I135V, T139L, T200TA, I202IV, Q207H, H208HY, R211K, F214L, E224ED, L228H D186DY
>1327-30708| codons 38-247
CTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLQKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNELPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDYLYVSSDLEIGQHRAKVEELRHYLLKWGLFTP
DQKHQKDPPFHWMGYELHPDKWTVQPIVLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, I84V, L90M L10F, G73T I13M, K14KR, I15V, K20V, E35D, M36I, I62V, L63P, I64V, E65D, I66IV, A71I, I72IM, I85IV, I93L  
>1327-30708| codons 4-99
TLWQRPFVTMRVGGQLVEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVRQYDQVP
VDVCGHKIMTTVLVGPTPVNVVGRNLMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006