Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1327 | 1327-30708 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70KR, L74V, M184V, T215F | K219Q | K101DEHQ, Y181C, G190S | V106VI, V118I, K122E, I135V, T139L, T200TA, I202IV, Q207H, H208HY, R211K, F214L, E224ED, L228H | D186DY |
| >1327-30708| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSITVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNELPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDYLYVSSDLEIGQHRAKVEELRHYLLKWGLFTP DQKHQKDPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, G73T | I13M, K14KR, I15V, K20V, E35D, M36I, I62V, L63P, I64V, E65D, I66IV, A71I, I72IM, I85IV, I93L |
| >1327-30708| codons 4-99 TLWQRPFVTMRVGGQLVEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFVKVRQYDQVP VDVCGHKIMTTVLVGPTPVNVVGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |