<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1325 1325-30630 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, Y115F, M184V, L210W, T215Y   K103N, Y181C K238N K43N, K122E, I135L, I178L, V179VI, G196E, T200A, L228R, V245E  
>1325-30630| codons 38-247
CTELENEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLKKNKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDLIICQYVDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTP
DKKHQKEPPFRWMGYELHPDNWTVQPIELP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, I47V, I54L, I84V, L90M L10F, L33F, Q58E, G73S, L89V I13V, I15V, K20T, E34EV, E35D, M36I, R41K, D60E, I62IV, L63P, I64L, I66F, A71V, V77VI, I93L  
>1325-30630| codons 4-99
TLWQRPFVTVKVGGQLTEALLDTGADDTIFVDINLPGKWKPKMVGGIGGFLKVREYEQVP
LEFCGHKVISTVLIGPTPVNVIGRNVMTQLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006