Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1325 | 1325-30630 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I47V, I54L, I84V, L90M | L10F, L33F, Q58E, G73S, L89V | I13V, I15V, K20T, E34EV, E35D, M36I, R41K, D60E, I62IV, L63P, I64L, I66F, A71V, V77VI, I93L |
| >1325-30630| codons 4-99 TLWQRPFVTVKVGGQLTEALLDTGADDTIFVDINLPGKWKPKMVGGIGGFLKVREYEQVP LEFCGHKVISTVLIGPTPVNVIGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, Y115F, M184V, L210W, T215Y | K103N, Y181C | K238N | K43N, K122E, I135L, I178L, V179VI, G196E, T200A, L228R, V245E |
| >1325-30630| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDVGDAFFSVPLDEDFRKYTAFTIPSLNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDLIICQYVDDLYVGSDLEIEQHRAKIEELRQHLWRWGFYTP DKKHQKEPPFRWMGYELHPDNWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |