Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1322 | 1322-30423 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, L210W, T215Y | K70Q | L100I, K101E, G190S | K43E, K49R, V60I, V106I, L109I, V118I, K122E, D123DE, I178IL, G196E, Q197K, T200A, E203V, Q207E, H208Y, R211K, K223Q, L228LH, V245KLMQ |
| >1322-30423| codons 41-247 LEEEGKISRIGPENPYNTPIFAIKKKNSDQWRKLMDFRELNKRTQDFWEVQLGIPHPAGI EKKKSITVIDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIF QSSMTKILEPFRKQNPDLVIYQYMDDLYVSSDLEIEKHRAKIVELREYLWKWGFYTPDKK HQQEPPFHWMGYELHPDKWTVQPIQLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82C, I84V, L90M | L33F, G73S, L89V | L10I, V11L, G16A, E34Q, K55R, R57K, L63P, H69Q, K70E, A71V, I72L, T91S, I93L |
| >1322-30423| codons 4-99 TLWQRPILTIKIAGQLKEALLDTGADDTVFQEMNLPGRWKPKIIGGIGGFVRVKQYDQIP IEICGQEVLSTVLVGPTPCNVIGRNVMSQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |