Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1532 | 1532-30821 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69T_T, K70R | D67G, K219Q | K103N | V108I | K64N, V90I, I135T, S162Y, D177E, Q207E, L228H, V245E |
| >1532-30821| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAINKKGSTRWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPEIVIYQYMDDLYVGSDLEIGQHRTKIEELREHLLRWGFTTP DQKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10FV, L33F, K43KT, T74TP | I13V, K14R, I15IV, K20KT, M36L, N37NS, R41K, K55R, I62V, I64V, H69HY | Q61QP |
| >1532-30821| codons 4-99 TLWQRPVVTVRVGGQLTEALLDTGADDTVFEELSLPGKWTPKLIGGIGGFVRVRQYDPVL VEICGYKAIGPVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |