Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2271 | 2271-30822 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | Unknown | 69 |
| 2 | NNRTI|NRTI|PI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I50IV, I54T, V82A, I84IV | K43T, G73GA, L89V | L10I, I13V, L19P, K20IM, E35G, M36I, I62V, L63P, C67CY, A71V |
| >2271-30822| codons 4-99 TLWQRPIVTVKIGGQPMEALLDTGADDTVLEGINLPGRWTPKMIVGVGGFTKVRQYDQVP IEIYGHKVIATVLVGPTPANVIGRNVLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K65R, Y115F, Q151M, M184V | A62V, K70T, V75I, F77L, F116Y | K103N | P225PH | S68K, V111VI, I135L, E138G, S162H, I167IV, I178IM, G196E, T200A, R211RAGT |
| >2271-30822| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFVIKRKDKTTWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKNKSVTVLDIGDAFYSVPLDKDFRKYTAFTIPSLNNGTPGIRYQYNVLPMGWKGSP AIFQHSMTKVLEPFRKQNPDMVIYQYVDDLYVGSDLEIEQHRAKIEELRQHLLTWGFTTP DKKHQKEHPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |