Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2268 | 2268-30808 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, L76V, I84V | L10IV, E35D, N37E, I62V, L63P, I64V, A71V, I72IT, V77T, V82VI, I93L |
| >2268-30808| codons 4-99 TLWQRPVVTIKIGGQLKEALLDTGADDTVLEDMELPGRWKPKIIGGIGGFLKVRQYDQVP VEICGHKVTGTVVTGPTPINVIGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| T69S_SS, L74V, L210W, T215Y | A62V | Y181C, G190A | A98G, V179D, K238T | K101Q, K122E, V189I, D192N, R211K | F61FS, L187LS |
| >2268-30808| codons 38-247 CTEMEKEGKISKIGPENPYNTPVSVIKKKDSSKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLQKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIDICQYMDDSYIASNLEIGQHRTKIEELRQHLWKWGFYTP DKKHQKEPPFLWMGYELHPDTWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |