Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1977 | 1977-30612 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, V82A, L90IM | G73S | L10I, I62V, L63P, A71V, I72E |
| >1977-30612| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIVGIGGFIKVRQYDQVP IEICGHKVESTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| K70R, L74I, M184V, T215F | T69G, V75S, K219Q | D67X, V90VI, I142V, S162A, Q174L, G196E, Q207E, L228H |
| >1977-30612| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKXSGRWRKISDFRELNKRTQDFWEIQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSP AIFQASMTKILEPFRKLNPDIVIYQYVDDLYVGSDLEIEQHRTKIEELREHLLRWGFFTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |