Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1784 | 1784-30520 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L90M | G73S | L10I, I13V, K20I, I62V, L63P, A71T |
| >1784-30520| codons 4-99 TLWQRPIVTVKIGGQLIEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQVP IEICGHKTISTVLVGPTPVNIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, K70R, M184V, T215F | K219Q | K103N, G190A | T39S, A98S, K122E, I135V, G196E, Q197A, T200A, Q207E, P225S, L228H, V245E |
| >1784-30520| codons 38-247 CSELEKEGKISKIGPENPYNTPVFAIKKKNSDRWRKLVDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVASDLEIEAHRAKIEELREHLLRWGFFTP DQKHQKESPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |