Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1053 | 1053-30402 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, I84V, L90M | L33F, G73T | L10I, K20R, L24F, E35D, M36I, N37D, K43Q, I62V, L63P, I64V, A71V, I72R, P79A |
| >1053-30402| codons 4-99 TLWQRPIVTIKIGGQLREALFDTGADDTVFEDIDLPGRWQPKLIGGIGGFVKVRQYDQVP VEICGHKVRTTVLVGATPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, L210W, T215F | K219Q | Y181C | T39E, V60VI, T69N, K102Q, I132IV, I135IV, Q174K, D177N, G196E, I202V, E203K, Q207E, H208HY, R211RK, D218E, L228H |
| >1053-30402| codons 38-247 CEEMEKEGKISKIGPENPYNTPIFAIKKKNSNKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKQKKSVTVLDVGDAYFSVPLDKDFRKYTAFTVPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKKNPNIVICQYMDDLYVGSDLEIEQHRTKVKELREYLWKWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |