Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1051 | 1051-30306 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, K70R, L74I, M184V, L210LW, T215F | D67S, K219E | K103N, Y181C | A98AG, V108I | V60I, T69N, L109I, I135T, G196E, D218E, L228H |
| >1051-30306| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKSSNRWRKIVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTIIDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIEQHRTKIEELRQHLWRWGFFTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I50V, I54V, V82A, L90M | L10F, V11VI, L33LF, K43T | I15V, G16A, K20KM, E34EQ, D60E, I62V, L63P, K70T, A71V, I72T, Q92K |
| >1051-30306| codons 4-99 TLWQRPFITIKVAGQLMEALLDTGADDTVFQEMNLPGRWTPKIIGGVGGFVKVRQYEQVP IEICGHTVTGTVLVGPTPANIIGRNLMTKIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |