Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1050 | 1050-30305 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L10F, G73C | W6C, Q7E, I13V, Q18H, K20I, E35D, M36I, N37D, K55R, I62V, L63P, I72IM |
| >1050-30305| codons 4-99 TLCERPFVTVKIGGHLIEALLDTGADDTVLEDIDLPGRWKPKIIGGIGGFVRVRQYDQVP IEICGHKAMCTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, V75M, M184V, L210W, T215Y | K101E, Y181C, G190A | A98G, F227FL | T39TA, K43E, E44A, V60I, T107S, L109I, K122E, I135T, I167V, D177E, G196E, E203K, H208Y, R211K, K223E, V245E |
| >1050-30305| codons 38-247 CAELEEAGKISKIGPENPYNTPIFAIKKKNSTKWRKLMDFRELNKRTQDFWEVQLGIPHP GGLEKKKSVSVIDVGDAYFSVPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKVLEPFRKQNPEIVICQYVDDLYVASDLEIEQHRTKIKELRQYLWKWGFYTP DKKHQEEPPLLWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |