Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1049 | 1049-30304 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69S_SS, V75M, M184V, T215Y | K103N, Y181C, G190A | A98G | K64KR, K101R, K122E, H208Y, R211RKT, L228H, V245EK |
| >1049-30304| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIRKKDSSKWRKLMDFRELNKRTQDFWEVQLGIPHP GGLRKNKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVASDLEIGQHRTKIEELRQYLLTWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIKLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I47V, G48M, I54M, V82A, I84V, L90M | L33F, F53L, L89V | L10I, I13V, L19I, E34Q, N37NS, R57K, L63M, I64IM, I66F, A71V, G73D, Q92K, C95L |
| >1049-30304| codons 4-99 TLWQRPIVTVKIGGQIKEALLDTGADDTVFQEMSLPGRWKPKMVMGIGGLMKVKQYDQIM MEFCGHKVIDTVLVGPTPANVIGRNVMTKIGLTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |