Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1034 | 1034-30417 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54V, V82A, L90M | L33F, F53L, G73S, L89V | L19LI, N37D, R41K, L63P, A71V |
| >1034-30417| codons 4-99 TLWQRPLVTIKIGGQIKEALLDTGADDTIFEEMDLPGKWKPKIVGGIGGLVKVRQYDQIP IEICGHKVISTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69TADN, M184V, L210W, T215Y | T39N, K43E, E44A, K49R, V118I, K122E, D123N, I135IT, S162C, E169D, Q197QE, T200A, K223Q, L228R, V245K |
| >1034-30417| codons 38-247 CNELEEAGKISRIGPENPYNTPVFAIKKKDSNKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQCSMTKILDPFRKQNPDIVIYQYVDDLYVGSDLEIGEHRAKIEELRQHLWRWGFYTP DKKHQQEPPFRWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |