Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1808 | 1808-30730 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, G48Q, I54A, V82F, L90M | F53L | L10I, R41K, D60E, I62V, L63P, I64V, A71V, T74TS, V77I, I93L |
| >1808-30730| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGKWKPKLIQGIGGLAKVRQYEQVP VEICGHKVIGSVLIGPTPFNIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, Q151M, M184V, T215F | F116Y, K219Q | Y181C, G190A | V60I, T69N, K101Q, V111I, K122E, I135V, M164L, I167V, I178M, G196E, H208Y, R211A |
| >1808-30730| codons 38-247 CTEMEKEGKISKIGPENPYNTPIFAIKKKNSNRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLQKKKSVTVLDIGDAYYSVPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPMGWKGSP AIFQSSLTKVLEPFRKQNPDMVICQYVDDLYVASDLEIEQHRTKIEELRQYLLAWGFFTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |