Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1807 | 1807-30710 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82A, I84V, L90M | L10FV, V11I, Q58E, G73C | I15V, G16A, Q18H, K20L, M36I, K43R, Q61N, L63P, A71T, I72IV, I85V, Q92K |
| >1807-30710| codons 4-99 TLWQRPVITIKVAGHLLEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFVKVREYDNIP IEICGHKTVCTVLVGPTPANVVGRNLMTKIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, M184V, L210W, T215Y | K219R | K103N | A98G, V108I | K43Q, E44D, T69TN, V118I, K122E, I135T, I142V, S162C, K173Q, Q174R, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H, Q242H, V245E |
| >1807-30710| codons 38-247 CTELEQDGKISKIGPENPYNTPVFAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQCSMTKILEPFRQRNPEMVIYQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTP DRKHQEEPPFHWMGYELHPDKWTVHPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |