<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1807 1807-30710 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
I54V, V82A, I84V, L90M L10FV, V11I, Q58E, G73C I15V, G16A, Q18H, K20L, M36I, K43R, Q61N, L63P, A71T, I72IV, I85V, Q92K  
>1807-30710| codons 4-99
TLWQRPVITIKVAGHLLEALLDTGADDTVLEEINLPGRWRPKMIGGIGGFVKVREYDNIP
IEICGHKTVCTVLVGPTPANVVGRNLMTKIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, L74V, M184V, L210W, T215Y K219R K103N A98G, V108I K43Q, E44D, T69TN, V118I, K122E, I135T, I142V, S162C, K173Q, Q174R, D177E, I178M, T200A, E203K, Q207E, H208Y, R211K, K223E, L228H, Q242H, V245E  
>1807-30710| codons 38-247
CTELEQDGKISKIGPENPYNTPVFAIKKKDSNKWRKVVDFRELNKRTQDFWEVQLGIPHP
GGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP
AIFQCSMTKILEPFRQRNPEMVIYQYVDDLYVGSDLEIGQHRAKIKELREYLWKWGFYTP
DRKHQEEPPFHWMGYELHPDKWTVHPIELP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006