Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1708 | 1708-30513 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70R, L74I, M184V, T215F | K219Q | L100I, Y181I | V179D | K101KQ, D123E, Q174R, D177E, I178L, I195L, T200A, R211A, D218E, L228H |
| >1708-30513| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHP AGIQKKKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKRNPELDIIQYVDDLYVGSDLELGQHRAKIEELRQHLLAWGFFTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54M, V82A, L90M | L10FV, L33F, K43T, G73S | I13V, I15V, K20T, E35N, M36I, N37D, K55R, D60E, I62V, L63E, A71V, V77I |
| >1708-30513| codons 4-99 TLWQRPVVTVKVGGQLTEALLDTGADDTVFENIDLPGRWTPKLIGGIGGFMRVRQYEQVE IEICGHKVISTVLIGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |