Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1706 | 1706-30410 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54L, I84V, L90M | V11VI, L33LF, F53L, G73T | L10I, T12AP, I13V, G16A, D60E, L63P, I64V, A71V, I72IT, V77VI, I93IL |
| >1706-30410| codons 4-99 TLWQRPIIPVKIAGQLKEALLDTGADDTVFEEMNLPGRWKPKIIGGIGGLLKVRQYEQIP VEICGHKVTTTVLIGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184V, L210W, T215Y | V108I | T39TAEK, K43E, E44D, E53ED, K64R, A98S, K101Q, V118I, K122E, D123N, I135T, T200TAEK, E203K, Q207D, H208Y, R211K, K223Q |
| >1706-30410| codons 38-247 CKELEEDGKISKIGPDNPYNTPVFAIRKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP SGLQKKKSVTILDVGDAYFSIPLDENFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRKKIKELRDYLWKWGFYTP DKKHQQEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |