Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1705 | 1705-30409 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, I84V, L90M | L10F, L33F, G73S, L89V | I13V, I15V, L19I, K20V, E35N, M36I, N37T, R41K, I62V, L63P, I66F, A71V, P79A |
| >1705-30409| codons 4-99 TLWQRPFVTVKVGGQIVEALLDTGADDTVFENITLPGKWKPKIIGGIGGFMKVRQYDQVP IEFCGHKVISTVLVGATPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75M, M184V, L210W, T215Y | T39A, K43E, E44A, R83K, V118I, K122E, I135V, T200A, E203D, H208Y, R211K, L228R |
| >1705-30409| codons 38-247 CAELEEAGKISKIGPENPYNTPVFAIKKKDSTKWRKLMDFRELNKKTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIDELRQYLWKWGFYTP DKKHQKEPPFRWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |