Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1703 | 1703-30403 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, V82A, L90M | G73S, L89V | L10I, L33M, L63P, A71V, I85V, I93L |
| >1703-30403| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTIMEEMNLPGRWKPKIVGGIGGFMKVRQYDQIP IEICGHKVISTVLVGPTPANIVGRNVMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74I, V75T, M184V, L210W, T215Y | K219E | K103N, Y181C | V108I | E40F, K43E, K64KR, A98S, V118I, K122E, K173Q, Q174QK, V179VI, V189VI, T200TA, H208HY, R211RT, D218E, L228H |
| >1703-30403| codons 38-247 CTFLEEEGKISKIGPENPYNTPVFAIRKKNSTKWRKITDFRELNKRTQDFWEVQLGIPHP SGLKKNKSVTILDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRQKNPDIIICQYVDDLYIGSDLEIGQHRAKIEELRQYLWTWGFYTP EEKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |