Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1030 | 1030-30401 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, I84V, L90M | L10F, G73S | I13V, I15V, Q18H, K20I, I62V, L63P, I66FL, C67Y, H69R, A71V, I72M, V77VI |
| >1030-30401| codons 4-99 TLWQRPFVTVKVGGHLIEALLDTGADDTVLEEMNLPGRWKPKIVGGIGGFVKVRQYDQVP IELYGRKVMSTVLIGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, L210W, T215Y | K70T, K219R | T39A, E40F, K43E, V118I, K122E, D177E, I178L, G196GE, Q197QK, T200TA, H208Y, R211K, K223KQ, L228H, V245E |
| >1030-30401| codons 38-247 CAFLEEEGKISKIGPENPYNTPVFAIKKKNSDTWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPELVIYQYMDDLYVGSDLEIEKHRAKIEELRQYLWKWGFYTP DRKHQQEPPFHWMGYELHPDKWTVQPIELP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |