Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1028 | 1028-30325 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, V75M, L210W, T215Y | K219D | K103N | T39AV, V60I, K82R, A98S, V118I, K122E, I135T, S162H, D177N, G196E, H208F, R211N, L228LH |
| >1028-30325| codons 38-247 CVELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKLMDFRELNRRTQDFWEVQLGIPHP SGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQHSMTKILEPFRKQNPNIVIYQYMDDLYVGSDLEIEQHRTKIEELRQFLWNWGFYTP DDKHQKEPPFHWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | V11I, L33F, G73GCFV, T74P, L89AV | L10I, T12P, G16A, K20IV, E34EA, M36MI, R41K, Q61D, I62V, L63P, C67Y, A71V, I72L, V77I, I93L |
| >1028-30325| codons 4-99 TLWQRPIIPIKIAGQLVEALLDTGADDTIFAEINLPGKWKPKIVGGIGGFMKVRQYDDVP IEIYGHKVLVPVLIGPTPVNVIGRNVMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |