Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1026 | 1026-30321 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54V, V82A, L90M | F53L | L10V, K20R, E35D, M36I, N37E, R41RK, R57K, I62V, L63E, I64V, A71V, T74S, I93L |
| >1026-30321| codons 4-99 TLWQRPVVTIKIGGQLREALLDTGADDTVLEDIELPGKWKPKIVGGIGGLVKVKQYDQVE VEICGHKVIGSVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| Y115F, Q151M, M184V | A62V, V75I, F77L, F116Y | G190GE | T58N, S68G, V118I, K122E, I135K, K173Q, Q174K, E194EK, T200E, E203EK, E204K, Q207E, R211T, F214L, V245Q | P170PFLS, D186*E |
| >1026-30321| codons 38-247 CTEMEKEGKISKIGPENPYNNPVFVIKKKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAFYSIPLDEDFRKYTAFTIPSKNNETPGIRYQYNVLPMGWKGSP AIFQSSMTKILESFRQKNPDIVIYQYVDELYVESDLKIGQHREKIKKLREHLLTWGLTTP DKKHQKEPPFLWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |