<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1026 1026-30321 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54V, V82A, L90M F53L L10V, K20R, E35D, M36I, N37E, R41RK, R57K, I62V, L63E, I64V, A71V, T74S, I93L  
>1026-30321| codons 4-99
TLWQRPVVTIKIGGQLREALLDTGADDTVLEDIELPGKWKPKIVGGIGGLVKVKQYDQVE
VEICGHKVIGSVLVGPTPANIIGRNLMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
Y115F, Q151M, M184V A62V, V75I, F77L, F116Y G190GE   T58N, S68G, V118I, K122E, I135K, K173Q, Q174K, E194EK, T200E, E203EK, E204K, Q207E, R211T, F214L, V245Q P170PFLS, D186*E
>1026-30321| codons 38-247
CTEMEKEGKISKIGPENPYNNPVFVIKKKDGTKWRKLIDLRELNKRTQDFWEVQLGIPHP
AGLKKKKSVTVLDVGDAFYSIPLDEDFRKYTAFTIPSKNNETPGIRYQYNVLPMGWKGSP
AIFQSSMTKILESFRQKNPDIVIYQYVDELYVESDLKIGQHREKIKKLREHLLTWGLTTP
DKKHQKEPPFLWMGYELHPDKWTVQPIQLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006