Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1025 | 1025-30321 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54S, V82S | K43T | L10I, I15V, G16A, K20T, L38LF, R41K, L63P, I64V, A71V, T74S, V77I, I85V, I93L |
| >1025-30321| codons 4-99 TLWQRPIVTIKVAGQLTEALLDTGADDTVLEEMNFPGKWTPKMIVGIGGFSKVRQYDQIP VEICGHKVIGSVLIGPTPSNIVGRNLLTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, V75T, T215Y | A62V, K219NS | K103N, M230ML | K43E, E44D, K64KR, K82KR, W88C, K104KR, V111I, V118I, K122E, S162A, N175Y, G196GE, T200EIKV, I202IV, E203ED, R211RK, F214FL, D218E | L210ST |
| >1025-30321| codons 38-247 CTELEEDGKISKIGPENPYNTPVFVIRKKNSTKWRKVTDFRELNRRTQDFCEVQLGIPHP AGLKKNRSVTVLDIGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQYPDIVIYQYMDDLYVGSDLEIEQHRVKVDELRQHLTKWGLYTP ESKHQKEPPFLWLGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |