Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2243 | 2243-30826 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| L10I, I13V, A71T, V77VI |
| >2243-30826| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVLEEMNLPGRWKPKMIGGIGGFIKVRQYDQIL IEICGHKTIGTVLIGPTPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, K70G, L74V, Y115F, M184V, T215FL | K219Q | K103S, G190A | K65KE, D123E, I135T, K173KE, D177E, I202IV |
| >2243-30826| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKEKNSTGWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKSKSVTVLDVGDAFFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFREQNPEIVIYQYVDDLYVASDLEIGQHRTKVEELRQHLLRWGFLTP DQKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |