Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-2242 | 2242-30707 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10I, L19LV, N37T, D60E, I62V, L63P, I64V, A71V, I93L | T80I |
| >2242-30707| codons 4-99 TLWQRPIVTIKIGGQVKEALLDTGADDTVLEEMTLPGRWKPKLIGGIGGFVKVRQYEQVP VEICGHKVIGTVLVGPIPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L210W, T215Y | K219R | K103S, G190A | T39A, E44D, K49R, V60I, V90I, V118VI, K122E, D123E, S162D, E169D, Q207E |
| >2242-30707| codons 38-247 CAELEKDGKISRIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEIQLGIPHP AGLKKSKSVTVLDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILDPFRKQNPDIVIYQYMDDLYVASDLEIGQHRTKIEELREHLWRWGFYTP DRKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |