Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1903 | 1903-30612 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | Q58E | L10V, K14R, L19I, L63P, A71V, I93L |
| >1903-30612| codons 4-99 TLWQRPVVTIRIGGQIKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGFVKVREYDQIP IEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, T215F | K219Q | K122E, D123N, T139R, S162C, E169D, Q174K, I178L, V179I, D192H, T200I, R211K, F214L, K223R |
| >1903-30612| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTRWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSVPLDENFRKYTAFTIPSINNERPGIRYQYNVLPQGWKGSP AIFQCSMTKILDPFRKKNPDLIIYQYMDDLYVGSHLEIGQHRIKIEELRQHLLKWGLFTP DQKHQREPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |