Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1730 | 1730-30424 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I54M, I84V, L90M | L10F, L33F, Q58E | T12A, I13IV, G16A, L19I, E34Q, I62V, L63P, A71L, V77I, L89M, I93L |
| >1730-30424| codons 4-99 TLWQRPFVAVKIAGQIKEALLDTGADDTIFQEMNLPGRWKPKIVGGIGGFMKVREYDQVP IEICGHKLIGTVLIGPTPVNVIGRNMMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, T215Y | K219Q | Y181C, G190S | K101H | T39E, E44D, V60I, K64KR, V118I, K122E, I135K, E203Q, Q207D, H208Y, L210F, R211K, D218E, L228H |
| >1730-30424| codons 38-247 CEELEKDGKISKIGPENPYNTPIFAIRKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLHKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVSSDLEIGQHRTKIQELRDYLFKWGFYTP EQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |