<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1730 1730-30424 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46I, I47V, I54M, I84V, L90M L10F, L33F, Q58E T12A, I13IV, G16A, L19I, E34Q, I62V, L63P, A71L, V77I, L89M, I93L  
>1730-30424| codons 4-99
TLWQRPFVAVKIAGQIKEALLDTGADDTIFQEMNLPGRWKPKIVGGIGGFMKVREYDQVP
IEICGHKLIGTVLIGPTPVNVIGRNMMTQLGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74V, M184V, T215Y K219Q Y181C, G190S K101H T39E, E44D, V60I, K64KR, V118I, K122E, I135K, E203Q, Q207D, H208Y, L210F, R211K, D218E, L228H  
>1730-30424| codons 38-247
CEELEKDGKISKIGPENPYNTPIFAIRKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLHKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSKNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDIVICQYVDDLYVSSDLEIGQHRTKIQELRDYLFKWGFYTP
EQKHQKEPPFHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006