Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1729 | 1729-30617 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 10 |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46I, I47V, I50V, I54L | K43KT | I13V, K20KR, E35D, M36I, N37T, L63P, I64V, A71AV, P79PA |
| >1729-30617| codons 4-99 TLWQRPLVTVKIGGQLREALLDTGADDTILEDITLPGRWTPKIVGGVGGFLKVRQYDQIP VEICGHKVIGTVLVGATPVNIIGRNLLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74V, M184V, L210W | T215E, K219Q | K103N, Y181C | V108VI | T39A, V60I, I135T, I142V, S162A, G196E, E203K, R211K, D218E, L228H, Q242QH, V245Q |
| >1729-30617| codons 38-247 CAELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKVVDFRELNKRTQDFWEVQLGIPHP AGLKKNKSVTILDVGDAYFSVPLDKDFRKYTAFTIPSTNNETPGVRYQYNVLPQGWKGSP AIFQASMTKILEPFRKQNPDIVICQYVDDLYVGSDLEIEQHRTKIKELRQHLWKWGFETP EQKHQKEPPFHWMGYELHPDKWTVHPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |