<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1728 1728-30409 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, T69D, M184V, L210W, T215Y K219R K103N A98G, V108I T39A, E44D, V60I, V111I, V118I, K122E, R172K, D177E, I178FL, D192DN, T200A, E203D, H208Y, R211K, H221Y, L246*  
>1728-30409| codons 38-247
CAELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP
GGLKKNKSVTILDIGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFKKQNPELVIYQYVDDLYVGSNLEIGQHRAKIDELRQYLWKWGFYTP
DRKYQKEPPFLWMGYELHPDKWTVQPIV*P

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I47V, I54M, I84V, L90M V11VI, L89V L10I, I13A, K14KE, L19V, K20R, A22V, E34EQ, E35D, M36I, N37H, R41K, L63P, A71I, I72E, V82I, Q92K, I93L  
>1728-30409| codons 4-99
TLWQRPIITAEIGGQVREVLLDTGADDTVLQDIHLPGKWKPKIVGGIGGFMKVRQYDQIP
IEICGHKIEGTVLVGPTPINVIGRNVMTKLGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006