Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1728 | 1728-30409 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, M184V, L210W, T215Y | K219R | K103N | A98G, V108I | T39A, E44D, V60I, V111I, V118I, K122E, R172K, D177E, I178FL, D192DN, T200A, E203D, H208Y, R211K, H221Y, L246* |
| >1728-30409| codons 38-247 CAELEKDGKISKIGPENPYNTPIFAIKKKNSDKWRKLVDFRELNKRTQDFWEVQLGIPHP GGLKKNKSVTILDIGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFKKQNPELVIYQYVDDLYVGSNLEIGQHRAKIDELRQYLWKWGFYTP DRKYQKEPPFLWMGYELHPDKWTVQPIV*P |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I47V, I54M, I84V, L90M | V11VI, L89V | L10I, I13A, K14KE, L19V, K20R, A22V, E34EQ, E35D, M36I, N37H, R41K, L63P, A71I, I72E, V82I, Q92K, I93L |
| >1728-30409| codons 4-99 TLWQRPIITAEIGGQVREVLLDTGADDTVLQDIHLPGKWKPKIVGGIGGFMKVRQYDQIP IEICGHKIEGTVLVGPTPINVIGRNVMTKLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |