Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1727 | 1727-30402 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54M, L76V, I84V, L90M | L33F, G73S, L89V | L10I, I13V, E34Q, N37ST, I62V, L63P, I64L, I66F, A71V, V77I | P79PHSY |
| >1727-30402| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFQEMTLPGRWKPKIIGGIGGFMKVRQYDQVP LEFCGHKVISTVVIGYTPVNVIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| D67N, T69D, K70R, Y115F, Q151M, M184I | A62V, V75I, F77L, F116Y, K219Q | L100I, K103N | T39K, I50T, V118I, K122E, D123G, T165I, T200A, I202V, Q207E, F214L, L228H |
| >1727-30402| codons 38-247 CKEMEKEGKISKTGPENPYNTPVFVIKKKNSDRWRKLIDLRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAFYSIPLDEGFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP AIFQSSMIKILEPFRKQNPDIVIYQYIDDLYVGSDLEIGQHRAKVEELREHLLRWGLTTP DQKHQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |