<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1678 1678-30331 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, M184V, L210W, T215Y K219N K101KE, Y188L   K43N, E44D, V60VI, L109LV, V118I, K122E, D123E, I135T, E138EA, S162CY, V189VI, H208Y, R211K, D218E, L228H, V245K K102K*RW
>1678-30331| codons 38-247
CTELENDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP
AGLEWKKSVTVVDVGDAYFSIPLDEEFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSP
AIFQYSMTKILEPFRKQNPDIVIYQYVDDLLIGSDLEIGQHRTKIEELRQYLWKWGFYTP
ENKHQKEPPFHWMGYELHPDKWTVQPIKLP

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46I, I54V, I84V, L90M L33F, Q58E, N83D L10I, I13V, M36L, I62V, L63P, I64V, L89M  
>1678-30331| codons 4-99
TLWQRPIVTVKIGGQLKEALLDTGADDTVFEELNLPGRWKPKIIGGIGGFVKVREYDQVP
VEICGHKAIGTVLVGPTPVDVIGRNMMTQIGCTLNF

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006