Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1678 | 1678-30331 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, I84V, L90M | L33F, Q58E, N83D | L10I, I13V, M36L, I62V, L63P, I64V, L89M |
| >1678-30331| codons 4-99 TLWQRPIVTVKIGGQLKEALLDTGADDTVFEELNLPGRWKPKIIGGIGGFVKVREYDQVP VEICGHKAIGTVLVGPTPVDVIGRNMMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K101KE, Y188L | K43N, E44D, V60VI, L109LV, V118I, K122E, D123E, I135T, E138EA, S162CY, V189VI, H208Y, R211K, D218E, L228H, V245K | K102K*RW |
| >1678-30331| codons 38-247 CTELENDGKISKIGPENPYNTPIFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLEWKKSVTVVDVGDAYFSIPLDEEFRKYTAFTIPSTNNATPGIRYQYNVLPQGWKGSP AIFQYSMTKILEPFRKQNPDIVIYQYVDDLLIGSDLEIGQHRTKIEELRQYLWKWGFYTP ENKHQKEPPFHWMGYELHPDKWTVQPIKLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |