Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1667 | 1667-30319 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69T_EA, M184V, L210W, T215Y | D67G | Y181C, G190A | A98G, V179E | T39A, K43Q, W88C, S105T, D177E, R211T, L228H, V245E |
| >1667-30319| codons 38-247 CAELEQEGKISKIGPENPYNTPVFAIKKKGSTKWRKLVDFRELNKRTQDFCEVQLGIPHP GGLKKKKTVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIEICQYVDDLYVASDLEIGQHRTKIEELRQHLWTWGFYTP DKKHQKEPPFHWMGYELHPDKWTVQPIELP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | F53L, Q58E, G73S | L10I, G16A, I62V, L63P, A71V |
| >1667-30319| codons 4-99 TLWQRPIVTIKIAGQLKEALLDTGADDTVLEEMNLPGRWKPKIIGGIGGLVKVREYDQVP IEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |