Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1675 | 1675-30331 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, I54L, I84IV, L90M | L10F, L33F, G73GS | I13V, I15IV, K20R, E34A, E35D, M36I, N37E, K45KR, L63P, A71V, I72T, I93L | R57N |
| >1675-30331| codons 4-99 TLWQRPFVTVKVGGQLREALLDTGADDTIFADIELPGRWKPRMIGGIGGFLKVNQYDQIP IEICGHKVTSTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, L210W, T215Y | K219E | L100I, K101E | T39A, E44D, K49R, V118I, K122E, S162D, S163R, D177EG, I178M, G196E, E203KQ, D218DE, K223Q, L228H |
| >1675-30331| codons 38-247 CAELEKDGKISRIGPENPYNTPVFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGIPHP AGIEKKKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQDRMTKILEPFRKQNPGMVIYQYVDDLYVGSDLEIEQHRTKIQELRQHLWRWGFYTP EEKHQQEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |