Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1672 | 1672-30327 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| L74V, Y115F, Q151M | K219N | L100I, K103N | S68G, A98S, K122P, A158S, S162A, I178M, E203D, F214L, L228R | T69V, D113E |
| >1672-30327| codons 38-247 CTEMEKEGKISKIGPENPYNTPVFAIKKKDGVKWRKVVDFRELNKRTQDFWEVQLGIPHP SGIKKNKSVTVLDVGEAFFSVPLDPDFRKYTAFTIPSINNETPGIRYQYNVLPMGWKGSP SIFQASMTKILEPFRKQNPDMVIYQYMDDLYVGSDLEIGQHRTKIDELRQHLLRWGLTTP DNKHQKEPPFRWMGYELHPDKWTVQPIVLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| G48V, I54V, V82A, L90M | L10I, K43I, R57K, L63P, A71V, I93L |
| >1672-30327| codons 4-99 TLWQRPIVTIKIGGQLKEALLDTGADDTVLEEMNLPGRWIPKMIVGIGGFVKVKQYDQIP IEICGHKVIGTVLVGPTPANIIGRNLMTQLGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |