Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1674 | 1674-30327 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I84V, L90M | L10I, K20I, E35D, M36I, L63P, H69R, A71V |
| >1674-30327| codons 4-99 TLWQRPIVTIKIGGQLIEALLDTGADDTVLEDINLPGRWKPKMIGGIGGFIKVRQYDQIP IEICGRKVIGTVLVGPTPVNVIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, L74V, V75M, M184V, L210W, T215Y | K219R | L100I, K103N | T39A, K43Q, E44D, T69N, V118I, K122E, I135M, T200A, E203D, E204Q, Q207D, R211K, H221CY, L228R | I244Q, L246S |
| >1674-30327| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKDSNKWRKVMDFRELNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSMNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYVDDLYVGSDLEIGQHRAKIDQLRDHLWKWGFYTP DRKYQKEPPFRWMGYELHPDKWTVQPQVSP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |