Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1673 | 1673-30327 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, I84V, L90M | L10F, L33F, G73T | K14R, E34Q, N37D, R57K, L63P, A71V, I93L |
| >1673-30327| codons 4-99 TLWQRPFVTIRIGGQLKEALLDTGADDTVFQEMDLPGRWKPKMIGGIGGFVKVKQYDQIP IEICGHKVITTVLVGPTPVNVIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, T69D, V75M, M184V, L210W, T215Y | D67G, K219R | K103H, Y181C, G190A | V108I | T39A, K43Q, E44D, A98S, K101Q, V118I, K122E, D123E, D177E, G196K, Q207E, R211K, H221Y, L228H |
| >1673-30327| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKGSDKWRKLMDFRELNKRTQDFWEVQLGIPHP SGLQKHKSVTILDVGDAYFSIPLDEEFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVICQYVDDLYVASDLEIKQHRTKIEELREHLWKWGFYTP DRKYQKEPPFHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |