Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1022 | 1022-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | L10F, L33F, K43T, T74P | I13V, E35D, M36I, I62V, L63P, A71V, I72V, I93L |
| >1022-30317| codons 4-99 TLWQRPFVTVKIGGQLKEALLDTGADDTVFEDINLPGRWTPKLIGGIGGFVKVRQYDQVP IEICGHKVVGPVLVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, M184V, L210W, T215Y | K219N | K43N, V118I, E169D, Q174K, T200A, E203D, H208Y, R211K |
| >1022-30317| codons 38-247 CTELENEGKISKIGPENPYNTPVFAIKKKNSTKWRKLVDFRELNKRTQDFWEVQLGIPHP AGLKKKKSVTVLDVGDAYFSIPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILDPFRKKNPDIVIYQYVDDLYVGSDLEIGQHRAKIDELRQYLWKWGFYTP DNKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |