Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1021 | 1021-40701 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
| 2 | NRTI+NNRTI+RTV+TPV | 67 |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, M184V, L210W, T215Y | K103KNRS | A98G | E28EK, K43X, E44ED, K101KR, V118VI, K122E, I142V, S162SN, T165TI, T200A, R211K, L228H, A272P, I293V, E297Q, D324DE, I329L, E370D, A376S, T377L, T386I, K390R |
| >1021-40701| codons 1-399 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTELEXDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLRKSKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQNSMIKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTDAVQKISLESIVIWGKIPKFRLPIQKETWE |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| I54V, V82T, I84V | K43T | L10I, K20R, L24M, E35D, M36I, I62V, L63P, I64V, A71V |
| >1021-40701| codons 1-99 PQITLWQRPIVTIKIGGQLREALMDTGADDTVLEDINLPGRWTPKMIGGIGGFVKVRQYD QVPVEICGHKVIGTVLVGPTPTNVIGRNLLTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |