Isolate Data
Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
12-1021 | 1021-40701 | U.S. | 2004 | HIV1 | B | Plasma | None |
Treatment History
Order | Regimen | Weeks |
1 | PI|NRTI|NNRTI | NA |
2 | NRTI+NNRTI+RTV+TPV | 67 |
RT Sequence
NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
M41L, M184V, L210W, T215Y | K103KNRS | A98G | E28EK, K43X, E44ED, K101KR, V118VI, K122E, I142V, S162SN, T165TI, T200A, R211K, L228H, A272P, I293V, E297Q, D324DE, I329L, E370D, A376S, T377L, T386I, K390R, A400T |
>1021-40701| codons 1-400 PISPIETVPVKLKPGMDGPKVKQWPLTKEKIKALVEICTELEXDGKISKIGPENPYNTPV FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPGGLRKSKSVTVLDVGDAYFSIPL DEDFRKYTAFTIPSINNETPGVRYQYNVLPQGWKGSPAIFQNSMIKILEPFRKQNPDIVI YQYVDDLYVGSDLEIGQHRAKIEELRQHLWKWGFYTPDKKHQKEPPFHWMGYELHPDKWT VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVVPLTQEAE LELAENREILKEPVHGVYYDPSKELIAELQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA HTNDVKQLTDAVQKISLESIVIWGKIPKFRLPIQKETWET |
Protease Sequence
PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
I54V, V82T, I84V | K43T | L10I, K20R, L24M, E35D, M36I, I62V, L63P, I64V, A71V |
>1021-40701| codons 1-99 PQITLWQRPIVTIKIGGQLREALMDTGADDTVLEDINLPGRWTPKMIGGIGGFVKVRQYD QVPVEICGHKVIGTVLVGPTPTNVIGRNLLTQIGCTLNF |
References
Author | Title | Citation |
Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |