<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1020 1020-30317 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
V32I, M46L, I47V, G48L, I54M, V82A L24I, L33F, F53L, Q58E L10V, I13V, L63A, I72EV, T74S, V77I, L89M  
>1020-30317| codons 4-99
TLWQRPVVTVKIGGQLKEALIDTGADDTIFEEMNLPGRWKPKLVLGIGGLMKVREYDQIA
IEICGHKAVGSVLIGPTPANIIGRNMLTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, L74IV, M184V, L210W, T215Y K219N K103N, Y181C, G190A V108VI T39TA, E40EK, E44D, K101KR, D123E, I135T, V179IL, G196E, E203K, H208Y, R211K, K223E, F227Y, L228H  
>1020-30317| codons 38-247
CAKLEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP
AGLRKNKSVTILDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP
AIFQSSMTKILEPFRKQNPDILICQYVDDLYVASDLEIEQHRTKIKELRQYLWKWGFYTP
DNKHQEEPPYHWMGYELHPDKWTVQPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006