Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1020 | 1020-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| V32I, M46L, I47V, G48L, I54M, V82A | L24I, L33F, F53L, Q58E | L10V, I13V, L63A, I72EV, T74S, V77I, L89M |
| >1020-30317| codons 4-99 TLWQRPVVTVKIGGQLKEALIDTGADDTIFEEMNLPGRWKPKLVLGIGGLMKVREYDQIA IEICGHKAVGSVLIGPTPANIIGRNMLTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74IV, M184V, L210W, T215Y | K219N | K103N, Y181C, G190A | V108VI | T39TA, E40EK, E44D, K101KR, D123E, I135T, V179IL, G196E, E203K, H208Y, R211K, K223E, F227Y, L228H |
| >1020-30317| codons 38-247 CAKLEKDGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRELNKRTQDFWEVQLGIPHP AGLRKNKSVTILDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDILICQYVDDLYVASDLEIEQHRTKIKELRQYLWKWGFYTP DNKHQEEPPYHWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |