Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1023 | 1023-30317 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, L74V, M184I, L210W, T215Y | K219R | L100I, K103N | F227FL | E79ED, D123E, I135T, D177E, T200E, E203K, H208Y, R211K, K223E, V245T |
| >1023-30317| codons 38-247 CTELEKEGKISKIGPENPYNTPVFAIKKKNSTKWRKVVDFRDLNKRTQDFWEVQLGIPHP AGIKKNKSVTVLDVGDAYFSVPLDKEFRKYTAFTIPSTNNETPGIRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPEIVIYQYIDDLYVGSDLEIGQHREKIKELRQYLWKWGFYTP DRKHQEEPPLLWMGYELHPDKWTVQPITLP |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54L, V82A, L90M | L33F, Q58E, G73GS | L10V, I13V, I15IV, I62V, L63P, A71V |
| >1023-30317| codons 4-99 TLWQRPVVTVKVGGQLKEALLDTGADDTVFEEMNLPGRWKPKLIGGIGGFLKVREYDQVP IEICGHKVISTVLVGPTPANIIGRNLMTQIGCTLNF |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |