Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1586 | 1586-30813 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46L, I54V, V82A, L90M | Q58E, G73T | L10I, I13IM, K20IR, M36I, R57RK, I62V, L63P, I64IV, C67F, H69R, A71V |
| >1586-30813| codons 4-99 TLWQRPIVTMKIGGQLREALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVKEYDQVP VEIFGRKVITTVLVGPTPANIIGRNLMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, K70R, L74I, M184V, L210W, T215Y | K219Q | K103N | V60I, I94IL, V118I, K122E, I135V, S162D, D177N, V179I, G196E, H208HY, R211RK, D218DE, K223KQ, L228H, Q242H |
| >1586-30813| codons 38-247 CTELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGLPHP AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP AIFQDSMTKILEPFRKQNPNIIIYQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTP EQKHQQEPPFHWMGYELHPDKWTVHPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |