<!--#if expr="$title" --> <!--#echo var="title" --> <!--#else --> HIV Drug Resistance Database <!--#endif -->
Stanford University HIV Drug Resistance Database - A curated public database designed to represent, store, and analyze the divergent forms of data underlying HIV drug resistance.

Isolate Data

Patient Isolate Region Year Species Subtype Source Clone Method
12-1586 1586-30813 U.S. 2003 HIV1 B Plasma None

Treatment History
Order Regimen Weeks
1 PI|NRTI|NNRTI NA

Protease Sequence
PIMajorDRMs PIMinorDRMs Polys UnusualMuts
M46L, I54V, V82A, L90M Q58E, G73T L10I, I13IM, K20IR, M36I, R57RK, I62V, L63P, I64IV, C67F, H69R, A71V  
>1586-30813| codons 4-99
TLWQRPIVTMKIGGQLREALLDTGADDTVLEEINLPGRWKPKLIGGIGGFVKVKEYDQVP
VEIFGRKVITTVLVGPTPANIIGRNLMTQIGCTLNF

RT Sequence
NRTIMajorDRMs NRTIMinorDRMs NNRTIMajorDRMs NNRTIMinorDRMs Polys UnusualMuts
M41L, D67N, K70R, L74I, M184V, L210W, T215Y K219Q K103N   V60I, I94IL, V118I, K122E, I135V, S162D, D177N, V179I, G196E, H208HY, R211RK, D218DE, K223KQ, L228H, Q242H  
>1586-30813| codons 38-247
CTELEKEGKISKIGPENPYNTPIFAIKKKNSTRWRKIVDFRELNKRTQDFWEVQLGLPHP
AGLKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSVNNETPGIRYQYNVLPQGWKGSP
AIFQDSMTKILEPFRKQNPNIIIYQYVDDLYVGSDLEIEQHRTKIEELRQYLWKWGFYTP
EQKHQQEPPFHWMGYELHPDKWTVHPIVLP

References
Author Title Citation
Baxter, JD Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. J Virol, 2006