Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1584 | 1584-30723 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, V82A, L90M | L10F, L33LI, L89V | T12Q, I13V, Q18H, L19IT, K20M, M36IT, P39PA, I62V, L63P, A71T, I72T |
| >1584-30723| codons 4-99 TLWQRPFVQVKIGGHTMEALLDTGADDTVIEETNLAGRWKPKIIGGIGGFVKVRQYDQVP IEICGHKTTGTVLVGPTPANIIGRNVMTQIGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, V75VIM, L210LW, T215Y | K101E, G190GS | T39A, K43KE, V60I, K122E, E138EG, I142V |
| >1584-30723| codons 38-247 CAELEEEGKISKIGPENPYNTPIFAIKKKDSTKWRKLMDFRELNKRTQDFWEVQLGIPHP AGLEKKKSVTVLDVGDAYFSVPLDEDFRKYTAFTIPSINNGTPGVRYQYNVLPQGWKGSP AIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVSSDLEIGQHRTKIEELRQHLWRWGFYTP DKKHQKEPPFLWMGYELHPDKWTVQPIVLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |