Isolate Data
| Patient | Isolate | Region | Year | Species | Subtype | Source | Clone Method |
| 12-1585 | 1585-30723 | U.S. | 2003 | HIV1 | B | Plasma | None |
Treatment History
| Order | Regimen | Weeks |
| 1 | PI|NRTI|NNRTI | NA |
Protease Sequence
| PIMajorDRMs | PIMinorDRMs | Polys | UnusualMuts |
| M46I, I54V, L76V, V82A, L90M | L33F, Q58E | L10I, I13V, K20R, E35D, M36I, N37S, R41RK, R57RK, I62V, L63P, A71V, I72V, I93L |
| >1585-30723| codons 4-99 TLWQRPIVTVKIGGQLREALLDTGADDTVFEDISLPGKWKPKIIGGIGGFVKVKEYDQVP IEICGHKVVGTVVVGPTPANIIGRNLMTQLGCTLNF |
RT Sequence
| NRTIMajorDRMs | NRTIMinorDRMs | NNRTIMajorDRMs | NNRTIMinorDRMs | Polys | UnusualMuts |
| M41L, D67N, T69D, V75M, M184V, L210W, T215Y | K219N | L100LI, K103N | T39A, K43Q, E44D, V90VI, V118I, K122E, A158S, S162A, V179VI, G196E, T200A, E203V, Q207D, H208Y, R211K, L228LH, V245Q |
| >1585-30723| codons 38-247 CAELEQDGKISKIGPENPYNTPVFAIKKKNSDKWRKLMDFRELNKRTQDFWEIQLGIPHP AGIKKNKSVTVLDVGDAYFSIPLDEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSP SIFQASMTKILEPFRKQNPDIIIYQYVDDLYVGSDLEIEQHRAKIVELRDYLWKWGFYTP DNKHQKEPPFHWMGYELHPDKWTVQPIQLP |
References
| Author | Title | Citation |
| Baxter, JD | Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir. | J Virol, 2006 |